21C Museum Hotel Louisville, Louisville ➤ Reviews, Rooms & Prices 2025

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About the Hotel

700 West Main Street, Louisville, Kentucky, United States, 40202

Great

8.7

9.3

/10

4.6

4.5

“The hotel's location is perfect, right in the heart of Whiskey Row and just a short walk to fantastic restaurants and attractions.”view full review

21C Museum Hotel Louisville is a 5-star boutique hotel and contemporary art museum showcasing over 9000 square feet of exhibition space. The property includes a highly-rated on-site restaurant, Proof on Main, known for its focus on local cuisine and bourbon. Offering 91 uniquely designed guest rooms, 21C Museum Hotel also features event spaces suitable for various gatherings.

Rooms & Amenities

Rooms at 21C Museum Hotel Louisville feature modern furnishings along with a premium Bryte Restorative Sleep Bed allowing customization of sleep experience. Each room is equipped with amenities such as flat-screen TVs, mini-bars, and coffee machines, ensuring guests have all they need for a comfortable stay.

Dining Options & Events

Dining at Proof on Main offers a curated menu boasting regional flavors and locally sourced ingredients. The hotel also hosts exclusive events such as the Fork & Bottle dinner series, featuring guest distillers and spirits from the area.

Leisure & Nearby Attractions

Leisure amenities include a spa offering various treatments and more than 9000 square feet of art exhibitions showcasing contemporary works. Guests can easily explore notable sites such as the Kentucky Museum of Art & Craft and the Muhammad Ali Center, all within half a mile of the hotel.

Services & Transportation

21C Museum Hotel Louisville is suitable for both personal and corporate events, with dedicated staff to assist in planning. Convenient public transport options include bus services, making it straightforward for guests to navigate the city.

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Select your room type

21C Museum Hotel Louisville offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals

Deluxe King Suite

2 persons

500 sq. feet

1 King-size bed

Shower

Coffee machine

room details

Atrium Suite

2 persons

575 sq. feet

1 King-size bed

Shower

Coffee machine

room details

Room Balcony

2 persons

315 sq. feet

1 King-size bed

Shower

Coffee machine

room details

Double Room Disability Access

2 persons

455 sq. feet

2 Double beds

Coffee machine

Heating

room details

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Facilities

21C Museum Hotel Louisville offers amenities for your comfortable stay and unforgettable experiences

Delicious Breakfast!

“The breakfast in room service was a fantastic deal, offering great variety and taste at an excellent price.” view full review

Relaxing Steam Room

“I absolutely loved unwinding in the steam room; it was the perfect way to relax after a long day.” view full review

Adjustable Lighting

“The adjustable light fixtures in the room allowed me to create the perfect ambiance, which I truly appreciated.” view full review

Fun Red Penguins!

“The playful red penguins that were moved around the hotel added a whimsical touch to our stay, making it more enjoyable.” view full review

General

No smoking on site
Free Wi-Fi
Parking
Safe deposit box
24-hour reception
Pets allowed
Rooms/ Facilities for disabled
Wheelchair access
Security
Luggage storage
Locker room
Allergy-free rooms
Lift
ATM/Cash machine
Smoke detectors
Electric vehicle charging station
Fire extinguishers

Sports & Fitness

Fitness centre
Yoga class

Guest Parking

Cookware/ Kitchen utensils

Services

Valet parking
Room service
Housekeeping
Laundry
Dry cleaning
Welcome drink

Dining

Restaurant
Bar/ Lounge area
Outdoor dining area

Business

Business centre
Meeting/ Banquet facilities
Fax/Photocopying

Children

Cots

Spa & Leisure

Spa & wellness centre
Sauna
Turkish bath
Steam room
Full body massage

Room features

Air conditioning
Heating
Mini-bar
Soundproofed rooms
Patio
Tea and coffee facilities
Ironing facilities

Bathroom

Free toiletries

Self-catering

Cookware/ Kitchen utensils

Media

Flat-screen TV

Room decor

Carpeted floor

21C Museum Hotel Louisville Location

700 West Main Street, Louisville, Kentucky, United States, 40202

Map view

700 West Main Street, Louisville, Kentucky, United States, 40202

City landmarks

Square

Fourth Street Live

2700 ft

Stadium

Louisville Slugger Field

1.0 mi

Event hall

Kentucky International Convention Center

3000 ft

Landmark

KFC Yum Center

2300 ft

Park

Waterfront Park

4400 ft

Church

Cathedral of the Assumption

2100 ft

Landmark

Freedom Hall

3700 ft

Museum

Thomas Edison House

1.3 mi

Landmark

Angel's Envy Distillery

5200 ft

Landmark

Jim Beam Urban Stillhouse

2900 ft

Bridge

Big Four Bridge

1.4 mi

Library

Louisville Free Public Library

4800 ft

Bridge

The Big Four Bridge

1.4 mi

Landmark

Old Forester Distilling

4000 ft

Landmark

West Main Historic District

1.4 mi

Museum

African American Heritage House Museum

1.3 mi

Park

Falls of the Ohio State Park

2.5 mi

Nearby

Museum

Louisville Slugger Museum & Bat Factory

600 ft

Museum

Muhammad Ali Center

1000 ft

Museum

Kentucky Science Center

500 ft

Museum

The Frazier History Museum

900 ft

Museum

Kentucky Museum of Art and Craft

300 ft

528 W Main St

Evan Williams Bourbon Experience

700 ft

Gallery

Flame Run Glass Studio and Gallery

1000 ft

500 W Main St

The Belvedere

900 ft

Night club

Jimmy Can't Dance

300 ft

801 W Main St

Michter's Fort Nelson Distillery

500 ft

Library

Sons of the American Revolution Genealogical Research Library

700 ft

120 N 10th St

Kentucky Peerless Distilling Co

1600 ft

401 W River Rd

Belle of Louisville Riverboats

2000 ft

Restaurants

Proof On Main

100 ft

702 West Main Street

Mussel & Burger Bar Downtown

200 ft

113 S 7th St Located in Louisville's Central Business District

Bristol Bar & Grille

400 ft

614 W Main St

Atlantic No. 5

600 ft

605 W Main St Located in Louisville's Central Business District.

Los Aztecas Mexican Restaurant

600 ft

445 E Market St

Vincenzo's Italian Restaurant

1500 ft

150 S 5th St

Jockey Silks Bourbon Bar

1600 ft

140 N 4th St 2nd Floor - West Tower

Dish on Market

1600 ft

434 W Market St

Quiznos

1800 ft

223 S 5th St

Swizzle Dinner & Drinks

1800 ft

140 N Fourth St 25th Floor

Cafe Magnolia

2000 ft

140 N 4th St Galt House Hotel

Getting around

City Centre

Louisville23 min · 1.2 mi

Airports

Louisville International Airport (SDF)18 min · 7.4 mi

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Property information and rules

Check-in

from 16:00-23:59

Check-out

until 11 am

Guest Parking

No parking available.

Internet

is available in for free.

Children & extra beds

Maximum capacity of extra beds in a room is 1.

Pets

Pets are allowed on request.

Year renovated:

2006

Number of floors:

Number of rooms:

Former name

21c Museum Hotel

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21C Museum Hotel Louisville, Louisville

About the Hotel

Rooms & Amenities

Dining Options & Events

Leisure & Nearby Attractions

Services & Transportation

Select your room type

Price and Room Availability Calendar

Facilities

General

Sports & Fitness

Guest Parking

Services

Dining

Business

Children

Spa & Leisure

Room features

Bathroom

Self-catering

Media

Room decor

21C Museum Hotel Louisville Location

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